"수술없이 암세포 99% 파괴"…획기적 기술 찾았다

https://v.daum.net/v/20231231220410738

"수술없이 암세포 99% 파괴"…획기적 기술 찾았다

과학자들이 '드릴'로 선택한 분자는 질병 진단에서 흔히 쓰이는 염료인 '아미노시아닌'이다. 이 분자는 바이오이미징 기술을 이용해 생체나 세포를 실시간 관찰하거나 암을 발견하는데 쓰이는 합성염료다. 물에서 안정적으로 유지되며 세포 표면에 잘 붙는 성질을 가진 덕분이다. 그런데 연구진은 이 분자가 단순히 암세포를 찾는 데 쓰일 뿐 아니라 암세포에 착 달라붙어 심하게 진동함으로써 암세포의 막을 찢을 수 있다는 사실을 알아냈다.

 

하루 빨리 대중화되기를......

 

https://www.nature.com/articles/s41557-023-01383-y

 

https://www.biorxiv.org/content/10.1101/2023.01.25.525400v1

Molecular Jackhammers Eradicate Cancer Cells by Vibronic-Driven Action

Through the actuation of vibronic modes in cell-membrane-associated aminocyanines, using near-infrared light, a distinct type of molecular mechanical action can be exploited to rapidly kill cells by necrosis. Vibronic-driven action (VDA) is distinct from both photodynamic therapy and photothermal therapy as its mechanical effect on the cell membrane is not abrogated by inhibitors of reactive oxygen species and it does not induce thermal killing. Subpicosecond concerted whole-molecule vibrations of VDA-induced mechanical disruption can be achieved using very low concentrations (500 nM) of aminocyanines or low doses of light (12) cm 2.80 mW cm² for 2.5 min), resulting in complete eradication of human melanoma cells in vitro. Also, 50% tumour-free efficacy in mouse models for melanoma was achieved. The molecules that destroy cell membranes through VDA have been termed molecular jackhammers because they undergo concerted whole-molecule vibrations. Given that a cell is unlikely to develop resistance to such molecular mechanical forces, molecular jackhammers present an alternative modality for inducing cancer cell death.